Showing posts with label opioids. Show all posts
Showing posts with label opioids. Show all posts

19 May 2015

"Home Brewed Morphine" From Yeast Now Possible With Beer-Making Kit As UC-Berkeley Scientist Team Produces Final Intermediary Chemical Reticuline

     Tuesday, 19 May 2015, BERKELEY, CA - A team of University of California at Berkeley scientists published yesterday online in the journal Nature Chemical Biology findings that the team finally has synthesized the last "stumbling block" being the intermediate step of producing reticuline in genetically modified yeast in order to perform the complicated chemistry necessary to convert sugar to morphine. The scientists reportedly say that it should now be possible to perform all the required steps to "brew" morphine at home.
     Dr. John Dueber a bioengineer at the University of California, Berkeley said,
"What you really want to do from a fermentation perspective is to be able to feed the yeast glucose, which is a cheap sugar source, and have the yeast do all the chemical steps required downstream to make your target therapeutic drug. With our study, all the steps have been described, and it's now a matter of linking them together and scaling up the process. It's not a trivial challenge, but it's doable." 
     Morphine currently requires a poppy harvest to manufacture. Not only could morphine brewed from genetically modified yeast become easier to produce the steps in the process can be modified by scientists to develop new types of painkillers. A comment to the published findings notes that "[i]n principle, anyone with access to the yeast strain and basic skills in fermentation would be able to grow morphine producing yeast using a home-brew kit for beer-making."
     The use of microscopic organisms to make drugs is not a new concept in medicine as for example insulin for people with diabetes already for decades has been make in genetically modified bacteria. Although currently it purportedly is "technically demanding" to make these yeast strains needed to brew morphine at home some already are calling for consideration of how these yeast strains might be regulated since currently they can be used to produce morphine and with expected modifications other opioids and painkillers.
     Readers interested in more information about the above can go to the link to the BBC Health News article directly below including therein a direct link to the above journal article preview as well as adjacent links to related BBC News articles including "Morphine: The Cheap, Effective Pain Drug Denied To Millions." Readers interested in going directly to the the Nature Chemical Biology preview published yesterday can go to the second link below and/or those interested in going to the full study article can go to the final third link below.

http://www.bbc.com/news/health-32780624

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1816.html

http://www.nature.com/articles/nchembio.1816.epdf?referrer_access_token=D8QJxSD78uATupwB4LFp7dRgN0jAjWel9jnR3ZoTv0Ocpo6Dbq1_LllflCKwtQuVGBuWKGy1kgdyCQ6uBeXKpIf4UqDvjnJOQpxbz9p3F_yOlBGwHd9BFdEAAbEDG8QTnZE7DImHAsPeOiDaSC5TGUwVk_qKkBzqxs6LYUc2nIs%3D&tracking_referrer=www.bbc.com

Copyright 2015 Martin P. All World Rights Expressly Reserved

19 April 2015

Heroin Free Delivery Like Pizza To A Nearby Corner Just A Call Away Sweeps Over U.S. As Big Pharma And Physicians Dump Millions Addicted To Opioids

     Sunday, 19 April 2015, NEW YORK, NY - The largely unreported heroin epidemic now raging across the United States as addressed in a recent Ninth Amendment post is the direct result of a massively aggressive campaign (i.e. "pushing drugs") of large pharmaceutical companies' marketing based on obvious lies and compliant physicians obediently "suspending disbelief" that opioids are addictive many of whom in recent years made a fortune and/or generous tax-free "benefits" selling and dispensing opioids in huge numbers greater than any except hypertension medications but now dumping millions of painkiller addicted patients on the streets to become heroin addicts afraid of increased regulatory pressure reportedly with such subtle reminders as "personal visits" by drug enforcement authorities of physicians and even pharmacies notably since recent years' "crackdown" on the opioid and synthetic opioid "painkilllers" such as OxyContin, oxycodone aka Percocet, and most recently rescheduled hydrocodone aka Vicadin aka Lortab aka Norco.
     This of course was just the latest in an abysmally long series of DEA (home of the "international drug cartel prostitute sex party boys") unbelievably misguided, oblivious and/or worse darkly intentional policies "clamping down" on its latest drug scare which policy lays waste to those presumably for whose own good it would "regulate" meanwhile inuring to the direct benefit of those in the drug trade opening up as usual for drug syndicates vast new opportunities for explosive profit via the unregulated "dispensing" of drugs of unknown quality and composition and of course helping to insure the continued seeming perpetual employment of those invested in drug "enforcement" by further extending the permanent robust health of the illegal drug trade. As has been many times observed the DEA policies could not do a better job assisting the drug cartels (who in apparent thanks and encouragement give DEA agents weapons and other bribes and host DEA prostitute sex parties as recently detailed in the Ninth Amendment) than if the drug cartels where establishing the "drug enforcement" laws and policies themselves. This so much belabors the obvious as to be tiresome to repeat ad nauseum.
     Free market pressures coming to the rescue an industrious group from rural Mexico known has the "Xalisco Boys" has as detailed in The New York Times article below developed and is executing a currently apparently ideal local business model controlling manufacture, wholesale and retail sales (even giving free samples like drug reps and making follow-up customer service survey calls) to serve the heroin needs of those across the United States (without an already established heroin dealer home market) with just a telephone call and a nearby pickup of what usually is the less processed heroin known as "black tar" which according to the article can be injected or smoked. Advance planning is essential as The New York Times reports the Xalisco Boys maintain strict business hours of 7 AM to 7 PM. Readers interested in more information including about the reportedly recent threefold increase in largely publicly unreported heroin overdose deaths are directed to the below link.
     THE NINTH AMENDMENT DOES NOT PURPORT TO NOR DOES IT PROVIDE ANY MEDICAL ADVICE WHATSOEVER TO ANY PERSON WHATSOEVER AT ALL. READERS AND ALL IN NEED OF MEDICAL ADVICE MUST CONSULT THEIR PROPERLY LICENSED HEALTHCARE PROFESSIONAL.

http://www.nytimes.com/2015/04/19/opinion/sunday/serving-all-your-heroin-needs.html?_r=0

Copyright 2015 Martin P. All World Rights Expressly Reserved