27 September 2014

BMJ Study "Links" Benzodiazepine Anxiety And Related "Z-Class" Sleeping Medication Use To Increased Risk For Alzheimer's Disease

       Friday, 26 September 2014, NEW YORK, NEW YORK - The Ninth Amendment editorial board sincerely urges that readers not become unnerved nor anxious by the above heading to this post. Although the heading is accurate to its New York Times source which concerned readers may go to directly at any time via the link provided below the Ninth Amendment finds a few introductory words in order as literally millions of Americans suffer from anxiety and/or insomnia a great many of whom at some time(s) or even for quite extended periods of up to many years have taken or take one or more of the above two groups of drugs which together are known to the medical community as "sedative-hypnotics". The "benzo" primarily anxiety drugs include ones such as Xanax, Ativan, Valium and Klonopin which are of similar composition but differing periods of action. The "z-class" sleep medications include Ambien and Lunesta.
      The last thing the Ninth Amendment wants to do is make any readers anxious or lose sleep so please relax and allow us first to convey a few points. The above headline refers to a summary article in the New York Times describing a study by Canadian and French medical researchers recently published in the well-regarded British Medical Journal (BMJ). Because of the high degree of reader interest in this area the Times article so far has generated well over three hundred comments and counting in the digital edition.
       Although it is important for our interested readers to be aware of the content of this article (which itself links directly to the full study for those interested) because it could prove lucrative fodder for media hype the truth of the matter is that a great many of the commenters including physicians weighing in on the Times article make seemingly valid points calling into question several aspects of the study done on the basis of medical records rather than dedicated study participants which make any suggestion of a conclusion based on everything from the lack of value of information presented which did not contain dosage information to a lack of evidence of other factors which may have affected the "control group".
       One commenting M.D.,Ph.D. whose comment was the second published in the digital Times following the article went so far as to observe that "there is a fairly large scientific literature showing benzodiazepines reduce the deposition of amyloid as well protect from the toxicity of the abnormal protein. Thus there is substantial basis to believe that this class of medications might actually be protective from Alzheimer's. . . ." This statement is consistent with the observation by the physician chief editor in the Harvard Medical Newsletter a few years past that despite the recent large-scale demonization (largely among physicians who never had experienced ongoing severe anxiety or used them) of benzodiazepines especially in any longer-term use that his lifetime of medical practice experience showed that long-term and even lifetime use of this class of medications was indicated in some patients for whom they had meant a huge improvement in quality of life for persons who might otherwise forever be virtually immobilized or unable to interact with others and society overall without constant overwhelming anxiety.
       This extended to the seemingly incomprehensible math used to reach any conclusion other than one that was unproven and premature at best. None of the physicians commenting found the study to be persuasive of the assertion of any causal "link" as implied in the Times headline reflected above. At best they concluded the demonstrated relationship might be stretched to the limit as an "association".  Many also took the Times to task for publishing an article of such personal medical interest to so many readers on this topic which was written by one with no recognized nor noted medical credentials at all must less a physician specializing in this field.
       Many of these points are touched on in the Ninth Amendment's comment to the Times article published earlier today in the Times digital edition. It is followed immediately by a link to the article itself which includes the 300+ comments published as of this posting as well as incorporating a direct link to the full study as published in the BMJ.
       THE NINTH AMENDMENT CANNOT AND DOES NOT PROVIDE NOR PURPORT TO PROVIDE ANY MEDICAL ADVICE TO ANYONE AT ALL. READERS MUST SEEK ALL MEDICAL ADVICE FROM A PROPERLY LICENSED MEDICAL PROFESSIONAL WHICH THE NINTH AMENDMENT IS NOT.

Ninth Amendment New York Times Digital Published Comment:




BigMartin

 waronnothing 27 minutes ago

With all due respect if the New York Times wishes to publish a medical column which greatly concerns a vast portion of the population who are ill and often suffer relentlessly even to the point of incapacity to interact or even meaningfully function at all with no other effective treatment available in this country the Ninth Amendment log at www.waronnothing.blogspot.com (which has no formal medical training whatsoever) respectfully suggests that rather than having it authored by one with apparently no formal medical credentials at all much less being a physician yet herself describes the subject as "a study designed with particular care" lasting for years yet then attempts to summarize in a few brief paragraphs that the Times has made a rather poor choice of one with authority meaningfully to interpret and present the information before ending the scant piece with an ominous quote from a physician making the pithy comment essentially that "Hey it's your life if you want to end it prematurely in a tragic mental void to pop a few sleeping pills be my guest". This is unhelpful just the type of medical advice a patient presumably would run from but for their suffering if it sounds as if they might get a prescription and some relief now that in the United States if one wishes to practice medicine there seems little point in enduring medical training and associated staggering debt to get an M.D. when one can get a G.E.D. join the DEA and "practice" medicine with no license at all.

Ninth Amendment New York Times SUBMITTED Comment 2 :



BigMartin
 waronnothing 

The Ninth Amendment log at www.waronnothing.blogspot.com (which has no medical expertise whatsoever) weighs in again on observing that comments here appear to be "all over the map". This confirms our earlier concern that this medical summary overall is not very helpful and should be presented ideally by a physician recognized as specializing in this area such that more readers might be left with a better more consistent understanding of what the underlying study did or did not conclude with some reasonable degree of assurance of the causal relationship of these drugs if any to the onset or course of Alzheimers Disease. This charged topic clearly is a matter of some importance to much of the population. The apparent lack of authority and consistent understanding here then seems to be addressed by the practice akin to opening "forums" where the value of each contribution is basically anyone's guess. We suggest that the Times consider following up this piece by one who might give readers more assurance of what was learned and most importantly what practical use they might make of that information. This is probably most helpful for those suffering from the underlying conditions the drugs are meant to treat to a degree of severity and for such a duration that those who have not experienced such extreme symptoms may not comprehend that they may drive one mentally into a hopeless condition regardless of their predisposition to depression when there seems no viable relief in sight.

New York Times Article:


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